MIND GROUP (HK) LIMITED
ORIENT AEROSOL GROUP (HK) LIMITED
FIRSTUNION GROUP HEALTH & LIFE SCIENCE RESEARCH INSTITUTE
SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY
CHINESE ACADEMY OF SCIENCES
NON-ADDICTIVE FUNCTIONAL SUBSTANCE RESEARCH AND DEVELOPMENT JOINT LABORATORY
OTAZ – Strategic Value Proposition
Your Trusted ODM Partner in Health & Wellness Vaporization.
We deliver reliable innovation and manufacturing excellence
We are committed to going beyond the conventional ODM model. By integrating cutting-edge R&D,
vaporization technology, herbal extraction, safety and efficacy verification, and large-scale
manufacturing with deep market insights, we provide end-to-end empowerment for leading health
and wellness companies—from concept to market
The Advanced Technology Institute(ATI )
Institute of Fundamental Science and Technical Support
Engage in the research of new materials and process such as advance ceramics,
thermal processing, and highperformance fibers.Study the indepth atomization mechanism
to achieve the best atomization effect.
Institute of Health Research & Life science
Mainly engaged in the research of atomized substances and functional
substances(herbal extract liquid) .Ensure the compliance and safety of products
through chemical analysis, biological analysis, pharmacological and
toxicological research and clinical verification of substances.
Institute of Product platform research & technical support
Conduct research on technological innovation and product development. Introduce the latest
heating methods, study the in-depth heating mechanism, utilize computer analysis and
optimize air flow, taste and thermal field distribution in order to achieve the best taste
and sensation
Research Team of Health and Wellness
As a key research institute for Shenzhen enterprises, the Institute of Life Sciences for Health has a R&D laboratory of nearly 1,000
square metres, and its scientific research backbone consists of more than a dozen experienced PhDs in chemistry, pharmacy, medicine,
physics, mechanics, etc. The Institute integrates domestic advantageous resources and cooperates with a number of national research
institutes. The research institute integrates domestic advantageous resources and cooperates
① set up the ‘Joint Laboratory of Brain Science and Life Health’ with the Institute of Brain Cognition and Brain Disease of theChinese
Academy of Sciences, with the research direction of the development of non-addictive functional substances;
② carry out scientific research with the School of Environment and Climate of Jinan University on the generation of aerosols, particle size
detection, and respiratory targeting settlement;
③ carry out the theoretical research on ultrasonic Theoretical research on nebulisation technology;
④ In-depth cooperation with the Drug Non-clinical Safety Evaluation Centre of the Institute of Traditional Chinese Medicine of the China
Academy of Traditional Chinese Medicine, which can test and evaluate the safety and effectiveness of the non-addictive functional
nebulising solution of nebulised inhalation according to non-GLP or GLP standards.
Herbal Wellness Nebulizer（inhaler)
Nebulizer
Medical Class II device(WE HAVE IT NOW!!)
Regular nebulizer
(Customizable )
The product is divided into two parts, nebulizer + atomizing herbal liquid. According to different national regulations, the
nebulizer can be a medical class II certificated heating nebulizer(WE HAVE IT NOW！！) or an general nebulizer devices
(similar with current nicotine vape); the raw materials of essence (atomizing liquid) are from herbal medicine, functional food,
natural plants, etc., it has regimen, health care, prevention, treatment and other functions. All these function essence and
device can be customized.
Functional Essence(herbal liquid)
- Existing essence
- Customized mixed essence
- Customizable new essence
HERBAL PLANT
Herbal plants are commonly referred to as “pharmaceutical botany,” which
refers to medicines made from plants or their extracts. The definition of
pharmaceutical botany typically means “medicines used in treatment are
plants or extracts (including whole extracts or partial extracts).
HOMOLOGY OF HERBAL MEDICINE AND FOOD
The history of Western herbal medicine can be traced back about 3000 years,
when treatment methods included the use of plants and herbs, as well as exercise,
rest, and therapeutic bathing. Hippocrates, known as the father of medicine, some
of his aphorisms such as “Let food be your medicine and medicine be your food”
are still quoted today, reflecting the connection between food and medicine.
AEROSOL INHALATION
The basic principle of nebulization therapy is to transform drug solutions (or
suspensions) into aerosols through a nebulizer device, which are then
inhaled through the respiratory tract to treat diseases. The tiny droplets of
the aerosol are suspended in the gas to form an aerosol, which is inhaled
into the airways and lungs through the mouth, nose, or artificial airways
(including tracheal intubation and tracheostomy tubes), thus achieving the
purpose of treatment.
What is Arecoline Extract（槟榔碱）?
Arecoline Extract is a compound derived from the seeds of the areca nut (Areca catechu L.), which contains the active ingredient arecoline. The areca nut has a long history of cultural use in Asia,
East Africa, and the Western Pacific, where it is often chewed for its relaxing, stimulating, and pleasurable effects.
Benefits and Effects of Arecoline Extract
- Nervous System
- Enhancing Cognitive Abilities: Research indicates that arecoline can increase the number of neural memory cells, enhance learning capabilities, and improve cognitive functions. In
patients with Alzheimer’s disease (AD), arecoline has been shown to improve cognitive impairments and memory.
- Antidepressant Effects: Arecoline can regulate the secretion of monoamine neurotransmitters (such as dopamine, serotonin, and norepinephrine), thereby exerting antidepressant
effects.
- Improving Neurodegenerative Diseases: As a muscarinic acetylcholine receptor (mAChR) agonist, arecoline can cross the blood-brain barrier, activate central M receptors, and
stimulate the hypothalamic-pituitary-adrenal (HPA) axis, thus improving neurodegenerative diseases.
- Digestive System
- Promoting Intestinal Motility: Arecoline can stimulate the contraction of intestinal smooth muscles, promote intestinal motility, and improve gut health. It achieves this by activating
muscarinic acetylcholine receptors (M3) and voltage-gated potassium channels, thereby increasing the amplitude of intestinal smooth muscle contractions.
- Antiparasitic Properties: Arecoline has antiparasitic properties that can alleviate symptoms such as vomiting, diarrhea, and intestinal obstruction caused by parasites.
- Cardiovascular System
- Regulating Lipid Levels: Arecoline Extract can lower total cholesterol, triglycerides, and the atherosclerosis index. It works by inhibiting the activity of acyl-CoA:cholesterol
acyltransferase (ACAT) in the intestines and pancreatic cholesterol esterase (pCEase), thereby reducing cholesterol levels in the plasma.
- Other Effects
- Antibacterial Properties: Arecoline Extract has antibacterial properties that can inhibit the growth of certain bacteria and fungi.
- Oral Health: In some cultures, areca nut is chewed to promote oral hygiene, but this practice is also associated with significant oral health risks.
What is Caffeine（咖啡因）?
Caffeine is a natural central nervous system stimulant belonging to the xanthine alkaloid class of compounds. It is widely found in various plants, such as coffee beans, tea leaves, cocoa beans, and
certain herbal plants. Caffeine is one of the most widely used central nervous system stimulants globally, commonly used for invigorating the mind and enhancing concentration.
Benefits and Effects of Caffeine
- Stimulating the Mind
- Effect: Caffeine can quickly enhance alertness and attention, reducing feelings of fatigue.
- Mechanism: Caffeine works by blocking adenosine receptors in the brain, reducing the effects of adenosine. Adenosine is a neurotransmitter that causes fatigue and drowsiness. By blocking
adenosine receptors, the excitability of the brain increases, making a person feel more awake and alert.
- Enhancing Cognitive Function
- Effect: Caffeine can improve attention, reaction speed, and cognitive abilities.
- Mechanism: Caffeine increases the levels of dopamine and norepinephrine in the brain, enhancing neural transmission efficiency and thereby improving cognitive function.
- Improving Athletic Performance
- Effect: Caffeine can enhance endurance and reduce exercise fatigue.
- Mechanism: Caffeine increases fat oxidation and reduces glycogen consumption, thereby prolonging exercise time. Additionally, caffeine can also reduce muscle soreness after exercise.
- Relieving Headaches and Migraines
- Effect: Caffeine can alleviate symptoms of headaches and migraines.
- Mechanism: Caffeine works by constricting blood vessels and reducing inflammation, thereby relieving headaches and migraines. Moreover, caffeine is often added to some painkillers to
enhance their effectiveness.
- Boosting Metabolism
- Effect: Caffeine can increase the metabolic rate, which is helpful for weight loss.
- Mechanism: Caffeine stimulates the central nervous system, increasing fat oxidation and energy expenditure, thereby raising the metabolic rate.
- Improving Mood
- Effect: Caffeine can enhance mood and reduce feelings of depression.
- Mechanism: Caffeine increases the levels of dopamine in the brain, improving mood and a sense of well-being.
What is Guarana（瓜拉纳）?
Guarana (Paullinia cupana), also known as Brazilian cocoa, is an extract from the seeds of a climbing shrub native to the Amazon Basin in Brazil. Guarana seeds contain a high concentration of caffeine, up
to 3-4 times that of coffee beans. In addition to caffeine, guarana also contains theobromine, theophylline, xanthine derivatives, tannins, and catechins, epicatechins, and procyanidins.
Benefits and Effects of Guarana
- Boosting Energy and Reducing Fatigue：
- Guarana’s high caffeine content gives it significant invigorating and fatigue-relieving effects. Studies have shown that guarana can significantly increase glycogen reserves in the liver of mice,
helping the body maintain blood sugar levels during exercise and providing more energy to combat fatigue.
- Optimizing Cognitive Function and Attention：
- Guarana may help optimize cognitive function and enhance attention. One study indicated that, compared to a placebo, the combination of guarana and multivitamins can better optimize
cognitive function, improving the accuracy and speed of test performance.
- Antioxidant Properties：
- Guarana contains various antioxidant components, such as catechins and procyanidins, which can help eliminate free radicals in the body and reduce oxidative stress.
- Anti-obesity Potential：
- Guarana may have the potential to inhibit fat formation. Research has found that guarana can downregulate the expression of pro-adipogenic genes and upregulate the expression of anti
adipogenic genes, thereby achieving an anti-lipogenic effect.
- Cardiovascular Health：
- Guarana may help lower cholesterol levels in the blood, strengthen blood vessel walls, prevent blood vessel blockages and cerebrovascular diseases, and fortify the heart, effectively preventing
myocardial infarction and heart failure.
- Digestive Health：
- Guarana can stimulate appetite, enhance gastrointestinal function, aid digestion, increase nutrient absorption, and improve digestive system function.
- Beauty and Skin Health：
- Guarana can supply nutrients to the skin, eliminate acne, blackheads, and dark spots, and make the skin smooth and radiant, maintaining youthful beauty.
What is Cordyceps（冬虫夏草）?
Cordyceps is a genus of precious medicinal fungi belonging to the family Clavicipitaceae. Among them, the most famous are Cordyceps sinensis (winter worm summer grass) and Cordyceps
militaris (artificially cultivated). Cordyceps sinensis is mainly found in high-altitude areas, such as the Tibetan Plateau in China, while Cordyceps militaris, also known as Northern Cordyceps, can be
standardized through artificial cultivation and is suitable for vegetarians.
- Cordyceps sinensis (Winter Worm Summer Grass): Formed by the parasitism of Cordyceps fungus on the larvae of the bat moth, it has a unique club-like shape.
- Cordyceps militaris (Northern Cordyceps): Also known as artificial Cordyceps, it can be standardized through artificial cultivation. Its main components include cordycepin, cordyceps
polysaccharides, and cordycepic acid.
Benefits and Effects of Cordyceps
- Boosting the Immune System:
- The polysaccharides and triterpenes in Cordyceps can activate immune cells and enhance the function of the immune system.
- Antitumor and Anti-cancer:
- Cordyceps polysaccharides and cordycepin have the effect of inhibiting the growth of tumor cells and inducing apoptosis of cancer cells.
- Regulating Lipid and Blood Sugar Levels:
- Cordyceps can lower cholesterol and regulate blood sugar levels, which is beneficial for cardiovascular health.
- Protecting the Liver and Kidneys:
- Cordyceps can improve liver function and reduce the damage of drugs or toxins to the liver.
- Improving Respiratory System Issues:
- Cordyceps has the effect of relieving cough and asthma and can be used to treat chronic bronchitis and allergic rhinitis.
- Regulating Reproductive Function:
- Cordyceps can enhance male fertility, increase sperm count and quality, and has potential effects on treating male infertility.
- Anti-fatigue and Enhancing Physical Strength:
- Cordyceps can improve physical endurance and work efficiency and reduce fatigue.
- Anti-aging:
- The antioxidant components in Cordyceps help delay the aging process
What is EGCG（茶多酚）?
EGCG (Epigallocatechin Gallate) is a powerful antioxidant belonging to the catechin class of flavonoids, primarily found in green tea. It is the most abundant and biologically active
polyphenol in green tea, offering a wide range of health benefits.
Benefits and Effects of EGCG
- Strong Antioxidant Properties:
- EGCG can neutralize free radicals, reducing oxidative stress and protecting cells from damage. It is particularly beneficial for the skin, cardiovascular system, and brain. EGCG
is a potent antioxidant, with an antioxidant capacity 25 to 100 times higher than that of vitamin C or E.
- Anti-inflammatory Effects:
- EGCG can inhibit the production of pro-inflammatory molecules, helping to reduce chronic inflammation. It has shown significant effects in improving symptoms of inflammatory
bowel disease and arthritis.
- Metabolic Support:
- EGCG activates AMPK, promoting fat oxidation and glucose uptake, which helps regulate body weight, maintain healthy blood sugar and cholesterol levels. It activates specific
pathways to reduce liver fat production, preventing obesity-related complications.
- Cardiovascular Health:
- Through its antioxidant and anti-inflammatory actions, EGCG helps lower blood pressure and improve vascular function, reducing the risk of cardiovascular diseases.
- Neuroprotective Effects:
- EGCG may offer protective benefits for the brain, potentially reducing the risk of neurodegenerative diseases like Alzheimer’s. It extends the lifespan of worms, flies, and rats by
activating SIRT1, a deacetylase whose activity is associated with cell apoptosis and aging.
- Antibacterial and Antiviral Properties:
- EGCG has antibacterial and antiviral characteristics, inhibiting the growth of bacteria and viruses.
- Antitumor Effects:
- EGCG has been shown to inhibit the growth of various tumors, including breast cancer, lung cancer, liver cancer, and colon cancer.
- Immune Regulation:
- EGCG can modulate the function of immune cells, inhibiting T cell proliferation and dendritic cell maturation, reducing the secretion of inflammatory factors.
What Are Multi-Vitamins(复合维他命）?
Vitamin B12 (also known as cobalamin) is a water-soluble vitamin and an essential nutrient for the human body. It contains the mineral cobalt, making it the only vitamin with a metallic element.
B12 plays a crucial role in various physiological functions, particularly in the nervous system, blood health, and DNA synthesis.
Benefits and Effects of Multi-Vitamins
Supports Nervous System Health
Involved in myelin synthesis (the protective sheath around nerve fibers). Deficiency can lead to nerve damage, tingling, or numbness.
May help prevent neurodegenerative disorders (e.g., cognitive decline), with some studies linking B12 to Alzheimer’s risk.
Promotes Red Blood Cell Formation
Works with folate to prevent megaloblastic anemia (abnormally large, immature red blood cells).
Deficiency may cause fatigue, paleness, and shortness of breath.
Aids DNA Synthesis & Cell Metabolism
Essential for genetic material (DNA/RNA) production, supporting cell growth (e.g., immune cells, gut lining).
Regulates Homocysteine Levels
Lowers homocysteine (high levels are linked to heart disease and stroke), supporting cardiovascular health.
Boosts Energy Metabolism
Helps convert proteins and fats into energy, reducing fatigue (though it doesn’t directly “energize”).
What is Ginseng（人参）?
Ginseng (Panax ginseng C.A. Meyer) is a traditional herb with a history of thousands of years in Asian countries. It contains a variety of active ingredients, including steroidal saponins,
protopanaxadiol, and protopanaxatriol, collectively known as ginsenosides. Ginseng has been widely used in traditional medicine to treat a variety of diseases. In recent years, its antioxidant, anti
inflammatory, anti-tumor, immune-enhancing, energy-boosting, and sexual function-enhancing effects, as well as its benefits against cardiovascular diseases, diabetes, and neurodegenerative
diseases, have been confirmed by basic and clinical research.
The benefits and effects of ginseng are as follows:
What Are Its Benefits and Effects
- Antioxidant and Anti-inflammatory Properties:
- Ginseng has antioxidant and anti-inflammatory activities that can inhibit inflammatory responses. For example, the saponin components in ginseng can inhibit the NF-κB signaling
pathway, reducing the production of inflammatory factors.
- Immune System Enhancement:
- Ginseng can regulate the function of immune cells and enhance the immune system.
- Cardiovascular Health Improvement:
- Ginseng helps lower blood pressure, improve vascular function, and regulate lipid levels, thereby reducing the risk of cardiovascular diseases.
- Blood Sugar Regulation:
- Certain components in ginseng can regulate blood sugar levels and have an auxiliary therapeutic effect on diabetes patients.
- Cognitive Function Improvement:
- Ginseng has protective effects on the brain and helps reduce the risk of neurodegenerative diseases such as Alzheimer’s disease.
- Anti-tumor Effects:
- Ginseng has been proven to inhibit the growth of various tumors, including breast cancer, lung cancer, liver cancer, and colon cancer.
- Energy and Sexual Function Enhancement:
- Ginseng is widely used to enhance energy and sexual function, improving libido and sexual performance.
- Anti-fatigue Effects:
- Ginseng can reduce fatigue and increase physical endurance.
- Anti-aging Properties:
- The antioxidant components in ginseng help delay the aging process.
